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The safety and effectiveness of Lariam for the treatment of malaria in pediatric patients below the age of 6 months have not been established. Since electrocardiographic abnormalities have been observed in individuals treated with Lariam (see PRECAUTIONS) and underlying cardiac disease is more prevalent in elderly than in younger patients, the benefits of Lariam therapy should be weighed against the possibility of adverse cardiac effects in elderly patients. Vaccinations with attenuated live bacteria should therefore be completed at least 3 days before the first dose of Lariam. To avoid relapse after initial treatment of the acute infection with Lariam, patients should subsequently be treated with an 8-aminoquinoline derivative (eg, primaquine). One 250 mg Lariam tablet should be taken once weekly in pediatric patients weighing over 45 kg.
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